External Therapy of Allergic and Inflammatory Dermatoses Using Advantan

Abstract

There are relatively few revolutionary inventions in dermatology that treat some skin diseases at least in magnitude. The introduction of topical steroids in the complex treatment of inflammatory and allergic dermatoses is precisely what this effect is.

For the first time in the early 1950s, the treatment of topical steroids in clinical practice is strengthening the position of treatment in the treatment of the most common dermatoses. These diseases have a very strong complex effect on various stages of the pathogenesis of skin diseases characterized by diseases, proliferation, disease manifestations, peeling, etc. It is explained by the metabolic effect of glucocorticosteroid hormones (GCSH) when applied locally:

• production of prostaglandins, leukotrienes, thromboxanes by blocking the activity of GKSH phospholipase A2;
• GCSH inhibits the synthesis of glycosaminoglycans, collagen and elastin, the release of histamine and other anti-inflammatory mediators, the release of mast cells, the appearance of Langerhans;
• immunocompetent cells inhibit the synthesis of nucleic acids (primary DNA) in basal and fibroblasts of the epidermis.

There is a wide range of vision for the use of topical glucocorticosteroids in the treatment of skin diseases in children and adults: seborrheic dermatitis, atopic dermatitis, various ways of hereditary and acquired erythroderma, eczema, hereditary bullous. epidermolysis, psoriasis, urticaria, lupus erythematosus, contact and allergic dermatitis and other allergic dermatoses.