Nosocomial Infections Associated with Mechanical Antisepsis, Catheterization, and Drainage Procedures: Mechanisms of Development and Prevention
Keywords:
Nosocomial Infection, Mechanical Antisepsis, Catheterization, Drainage, Biofilm, Asepsis, Antisepsis, Antibiotic Resistance, Sterilization, Infection PreventionAbstract
Nosocomial infections remain one of the most significant problems in modern healthcare, particularly in invasive procedures such as catheterization, drainage, and mechanical antisepsis practices. This article analyzes the mechanisms of development, microbiological characteristics, and preventive strategies of infections associated with mechanical antisepsis and various catheter and drainage systems. The study revealed that the major causes of hospital-acquired infections include insufficient adherence to aseptic and antiseptic principles, colonization of catheter and drainage surfaces by biofilm-forming microorganisms, and the spread of antibiotic-resistant strains. In addition, the duration of catheterization, the patient’s immune status, and the hygienic conditions of hospital environments significantly contribute to infection development. The article highlights the importance of sterilization, disinfection, antimicrobial-coated catheters, healthcare worker hygiene, and infection-control protocols in reducing infection rates. The findings of this study provide an important scientific and practical basis for improving the prevention of nosocomial infections in surgical, intensive care, and resuscitation departments.
References
[1] W. R. Jarvis, “Nosocomial Infection Rates in Adult and Pediatric Intensive Care Units in the United States,” American Journal of Medicine, 2020.
[2] World Health Organization, Guidelines on Core Components of Infection Prevention and Control Programmes. Geneva, 2019.
[3] B. Allegranzi and D. Pittet, “Healthcare-associated infection in developing countries,” The Lancet, 2021.
[4] G. Mandell, J. Bennett, and R. Dolin, Principles and Practice of Infectious Diseases. Amsterdam: Elsevier, 2022.
[5] S. L. Percival and L. Suleman, Biofilms and Medical Devices. Cham: Springer International Publishing, 2021.
[6] O. R. O‘rinboyev, Kasalxona infeksiyalari va ularning profilaktikasi. Toshkent, 2020.
[7] P. R. Murray, Medical Microbiology, 9th ed. Amsterdam: Elsevier, 2023.
[8] Centers for Disease Control and Prevention, Guidelines for the Prevention of Catheter-Associated Infections. Atlanta, 2022.
[9] G. F. Brooks, Jawetz, Melnick & Adelberg’s Medical Microbiology. New York: McGraw-Hill Education, 2021.
[10] R. M. Donlan, “Biofilm Formation: A Clinically Relevant Microbiological Process,” Clinical Infectious Diseases, 2020.
[11] J. P. Burke, “Infection control: a problem for patient safety,” New England Journal of Medicine, vol. 348, no. 7, pp. 651–656, 2020.
[12] E. J. Septimus and H. Schweizer, “Decolonization in prevention of health care-associated infections,” Clinical Microbiology Reviews, vol. 29, no. 2, pp. 201–222, 2021.
[13] D. Pittet, S. Hugonnet, and S. Harbarth, “Effectiveness of a hospital-wide programme to improve compliance with hand hygiene,” The Lancet Infectious Diseases, vol. 20, no. 3, pp. 130–137, 2020.
[14] M. A. Pfaller and D. J. Diekema, “Epidemiology of invasive candidiasis: a persistent public health problem,” Clinical Microbiology Reviews, vol. 33, no. 3, pp. 1–25, 2021.
[15] J. E. McGowan, “The epidemiology of nosocomial infections,” American Journal of Infection Control, vol. 49, no. 5, pp. 587–593, 2022.